Phenotype Image Detail

Image

Caption

Synarthroses and trachea/lung defects in the Fgfr2^tm4Lni/ Fgfr2^tm4Lni neonate. (A and B) Alizarin red staining. (CE) Alizarin red and alcian blue staining. (A and B) Knee-joint synarthrosis; arrowhead shows mineralized bridge between the femur and tibia of the mutant. (C) Fused sternebrae and asymmetric rib cage in the mutant (arrows). (D) Fusion of cervical vertebral arches (arrowheads) but lack of ossification of vertebral bodies. (E) Tracheal rings replaced by a cartilaginous sheath. (F) Reduced lungs in the homozygote (right) but not heterozygote (center), compared with wild-type (left).

Copyright

This image is from Eswarakumar VP, Proc Natl Acad Sci U S A 2004 Aug 24;101(34):12555-60. Copyright 2004 National Academy of Sciences, U.S.A. J:92433

Associated Alleles

Symbol	Name
Fgfr2^tm4Lni	fibroblast growth factor receptor 2; targeted mutation 4, Peter Lonai

Associated Genotypes

Allelic Composition	Genetic Background
Fgfr2^tm4Lni/Fgfr2^tm4Lni	Not Specified