Phenotype Image Detail

Image

Caption

Postnatal skeletal development of heterozygous Papss2^bm/Papss2⁺ (left) and homozygous Papss2^bm/Papss2^bm mutant (right) mice. Papss2^bm/Papss2^bm mice are characterized by a dome shaped skull, short thick tail and shortened but not widened limbs. The size difference becomes apparent over the first four weeks of life. There is a 50% reduction in the limb length and a 25% reduction in the axial skeletal size. Calcified bone and cartilage stained differentially with Alzarin red and Alcian blue respectively at P0, P10 and P30 (Inserts). Papss2^bm/Papss2⁺ (left) and Papss2^bm/Papss2^bm (right). Tibias of Papss2^bm/Papss2⁺ (left) and Papss2^bm/ Papss2^bm (right) showing the similar size in all skeletal elements at P0 and the slower increases in length at P10 and P30.

Copyright

This image is from Kurima K, Proc Natl Acad Sci U S A 1998 Jul 21;95(15):8681-5. Copyright 1998 National Academy of Sciences, U.S.A. J:49338

Associated Alleles

Symbol	Name
Papss2^bm	3'-phosphoadenosine 5'-phosphosulfate synthase 2; brachymorphic

Associated Genotypes

Allelic Composition	Genetic Background
Papss2^bm/Papss2^bm	LDJ/Le