Phenotype Image Detail

Image

Caption

Compared with the ⁺/Y control (left) the temporal bone surrounding the cochlea of the Phex^Hyp-Duk (right) is thickened with many areas of non-mineralization (arrows with stars). There is degeneration of the organ of Corti and spiral ganglion cells, especially in the apical turn (arrows). Endolymph volume is greater in the cochlea, there is an increased scala media, diminished scala vestibule as well as displacement of Reissner's membrane. Abbreviations: temporal bone (TB); scala tympani (ST); organ of Corti (OC); spiral ganglion (SG); scala media (SM); scala vestibuli (SV); Reisner's membrane (RM)

Copyright

This image is from Lorenz-Depiereux B, Mamm Genome 2004 Mar;15(3):151-61 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:88352

Associated Alleles

Symbol	Name
Phex^Hyp-Duk	phosphate regulating endopeptidase homolog, X-linked; hypophosphatemia, Duke

Associated Genotypes

Allelic Composition	Genetic Background
Phex^Hyp-Duk/Y	involves: BALB/cAnBomUrd