Phenotype Image Detail

Image

Caption

Electron microscopy analysis indicates structural abnormalities of germ cells. The nucleus is drastically deformed in some cells (B *). Vacuoles are seen inside the nucleus (A,B & E indicated by arrows). Acrosomal malformation with elongated projection is observed (C *). Sperm cells also have detached acrosome (B, C, D arrowheads). The cross-section (E) shows the bent tail next to the nucleus. +/+ wild-type sperm (F) showing normal acrosome and nuclear shape. Scalebar: 0.5um

Copyright

This image is from Kotaja N, Proc Natl Acad Sci U S A 2004 Jul 20;101(29):10620-5. Copyright 2004 National Academy of Sciences, U.S.A. J:91483

Associated Alleles

Symbol	Name
Fhl5^tm1Saco	four and a half LIM domains 5; targeted mutation 1, Paolo Sassone-Corsi

Associated Genotypes

Allelic Composition	Genetic Background
Fhl5^tm1Saco/Fhl5^tm1Saco	involves: 129S2/SvPas * C57BL/6