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Caption | (A & B) Tibia of 30 day old +/+ (A) and littermate Fgfr3tm2Wei/Fgfr3+ (B). (C & D) Higher magnification of the same sections as above. In the growth plate of the +/+, columns of proliferative and hypertrophic chondrocytes are seen. In the Fgfr3tm2Wei/Fgfr3+, the tibia is smaller and the columns are disrupted and shortened with very few cells in the proliferative and hypertrophic zones. (E & F) In situ hybridization of the growth plate with a probe for collagen type II, a marker for proliferating chondrocytes. (G & H) Staining for alkaline phosphatase activity in the growth plate marking the hypertrophic chondrocytes. Abbreviations: growth plate (GP); hypertrophic zone (HZ); porliferative zone (PZ) | ||||
Copyright | This image is from Wang Y, Proc Natl Acad Sci U S A 1999 Apr 13;96(8):4455-60. Copyright 1999 National Academy of Sciences, U.S.A. J:54829 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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