Phenotype Image Detail

Image

Caption

Skeletal preparation of +/+ (A, C, E & G) and Sox9^tm1Crm/Sox9⁺ (A, C, E & H). All endochondral skeletal elements of the Sox9^tm1Crm/Sox9⁺ are smaller and thinner then the +/+ littermates (A-F). The arrowhead in H shows that the bending site of the ulna is outside the ossification center. Cartilage staining of the +/+ ( I & K) and Sox9^tm1Crm/Sox9⁺ indicates Meckel's cartilage is interurupted (arrow) as well as bowing (arrowhead). In the E15.5 sternum section of the Sox9^tm1Crm/Sox9⁺ (N), the cartilage primordia is malformed (arrows). Abbreviations: Meckel's cartilage (Me); scapula (S); spine of scapula (Sp); humerus (H); radius (R); ulna (U); femur (F); fibula (Fi); tibia (T).

Copyright

This image is from Bi W, Proc Natl Acad Sci U S A 2001 Jun 5;98(12):6698-703. Copyright 2001 National Academy of Sciences, U.S.A. J:69875

Associated Alleles

Symbol	Name
Sox9^tm1Crm	SRY (sex determining region Y)-box 9; targeted mutation 1, Benoit de Crombrugghe

Associated Genotypes

Allelic Composition	Genetic Background
Sox9^tm1Crm/Sox9^+	involves: 129S7/SvEvBrd * C57BL/6 * CD-1