Phenotype Image Detail

Image

Caption

Compared with the +/+ control (A), advanced mineralization is seen in the bony ossicles of the middle ear of the Sox9^tm1Crm/Sox9⁺ (B). In the dorsal view of the skull, ossification centers of interparietal and supraoccipital bones are expanded in the Sox9^tm1Crm/Sox9⁺ (D). Advanced mineralization is found in the vertebrae throughout the vertebral columns of the Sox9^tm1Crm/Sox9⁺ (F & H). Mineralization is also seen in the cartilaginous regions between the vertebral body and the pedicles of dorsal arches. (J). (K & L) Hematoxylin/eosin stainin of sections of caudal vertebrae from E15.5 +/+ controls (K) and Sox9^tm1Crm/Sox9⁺ show the area of hypertrophic chondrocytes, indicated by arrowheads. Abbreviations: interparietal bone (Ip); supraoccipital bone (So); vertebral body (Vb); dorsal arch (Da); intervertebral discs (Id).

Copyright

This image is from Bi W, Proc Natl Acad Sci U S A 2001 Jun 5;98(12):6698-703. Copyright 2001 National Academy of Sciences, U.S.A. J:69875

Associated Alleles

Symbol	Name
Sox9^tm1Crm	SRY (sex determining region Y)-box 9; targeted mutation 1, Benoit de Crombrugghe

Associated Genotypes

Allelic Composition	Genetic Background
Sox9^tm1Crm/Sox9^+	involves: 129S7/SvEvBrd * C57BL/6 * CD-1