Phenotype Image Detail

Image

Caption

(A & B) The spleen of a Prkar1a^tm1Gsm/Prkar1a⁺ is enlarged by a tumor (white arrow). Histology shows splenic hemangiosarcoma with vascular channels lined by malignant endothelial cells (black arrows). (C & D) Left forelimb soft tissue mass (white arrow). Histology reveals myxoid fibrosarcoma comprised of highly anaplastic spindle cells (black arrows) with hyperchromatic enlarged nuclei and distinctive nucleoli dispersed in a myxoid stroma. (E & F) The liver (one lobe shown) has a multinodular (white arrows) appearance. Histology shows hepatocellular carcinoma with multiple nodules comprised of malignacy hepatocytes (black arrows) with loss of normal hepatic architecture. (G & H) Sarcoma mass involving the calvaria (white arrow) with distinct myxomatous areas (*). Insert in H: Typical stellate cell from myxomatous region. (I & J) Extradural lumbar chondrosarcoma causing compression and axonal degeneration in the spinal cord white matter (black arrow). Insert in J: A typical binucleated chondrocyte within the tumor. Scalebar: 50um B; 25 um D & F; 10 um H & J

Copyright

This image is from Veugelers M, Proc Natl Acad Sci U S A 2004 Sep 28;101(39):14222-7. Copyright 2004 National Academy of Sciences, U.S.A. J:93393

Associated Alleles

Symbol	Name
Prkar1a^tm1Gsm	protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, G Stanley McKnight

Associated Genotypes

Allelic Composition	Genetic Background
Prkar1a^tm1Gsm/Prkar1a^+	involves: 129X1/SvJ