Phenotype Image Detail

Image

Caption

A: The epidermis of the control and Slc27a4^wrfr/Slc27a4^wrfr appears similar, although the dermis appears more cellular in the Slc27a4^wrfr/Slc27a4^wrfr. At E17.5 the Slc27a4^wrfr/Slc27a4^wrfr epidermis is thicker with a flattened skin surface. At birth (PO) the Slc27a4^wrfr/Slc27a4^wrfr epidermis is on average three times thicker then the control (Bars indicate length), as well as having fewer and abnormally arranged keratohyalin granules (brackets). B: Staining for keratin 14 (K14) at E17.5 shows an increased thickness and flattening of the Slc27a4^wrfr/Slc27a4^wrfr. Keratin 6 (K6) is only express in the Slc27a4^wrfr/Slc27a4^wrfr. Loricrin (Lor) was not concentrated at the plasma membrane of granular cells in the Slc27a4^wrfr/Slc27a4^wrfr. C: E17.5 embryos incubated overnight show penetration into the Slc27a4^wrfr/Slc27a4^wrfr but not the control. D: Oil red O staining shows numerous fat droplets in the squamous layer of the Slc27a4^wrfr/Slc27a4^wrfr but not the control.

Copyright

This image is from Moulson CL, Proc Natl Acad Sci U S A 2003 Apr 29;100(9):5274-9. Copyright 2003 National Academy of Sciences, U.S.A. J:83282

Associated Alleles

Symbol	Name
Slc27a4^wrfr	solute carrier family 27 (fatty acid transporter), member 4; wrinkle free

Associated Genotypes

Allelic Composition	Genetic Background
Slc27a4^wrfr/Slc27a4^wrfr	involves: 129 * C57BL/6J