Phenotype Image Detail

Image

Caption

A & B: Median section through vertebrae of newborn wild-type littermate (left) and Arsb^tm1Cptr/Arsb^tm1Cptr (right) show the cartilaginous anlagen of the vertebrae of the Arsb^tm1Cptr/Arsb^tm1Cptr mouse is disturbed. C & D: Compared with the distal femur growth plate of the 4 week old wild-type littermate (left) there is widening of the growth plate of the Arsb^tm1Cptr/Arsb^tm1Cptr, also the columnar arrangement of chondrocytes is lost and there are ballooned and vaculated chondrocytes across the entire extension of the growth plate. E & F: In the liver of a 4 month old Arsb^tm1Cptr/Arsb^tm1Cptr (right), the sinus lining cells are storing large amounts of glycosaminoglycans. G & H: In the myocard section of a 4 month old Arsb^tm1Cptr/Arsb^tm1Cptr (right) there is storage of glycosaminoglycans in the intestinal cells. Magnification: A-H: X50

Copyright

This image is from Evers M, Proc Natl Acad Sci U S A 1996 Aug 6;93(16):8214-9. Copyright 1996 National Academy of Sciences, U.S.A. J:34831

Associated Alleles

Symbol	Name
Arsb^tm1Cptr	arylsulfatase B; targeted mutation 1, Christoph Peters

Associated Genotypes

Allelic Composition	Genetic Background
Arsb^tm1Cptr/Arsb^tm1Cptr	involves: 129P2/OlaHsd * C57BL/6J