Phenotype Image Detail

Image

Caption

(A) The stomach of an 11 month old wild type animal opened along the greater curvature. (B) Polyps (P) of different sizes cover the entire mucosa region of the stomach of a heterozygous Smad4^m4Mag littermate. (C) A section through the body of the wild type stomach shows the well organized mucosa and the muscularis region underneath. (D) A section through the body of the stomach of the heterozygous animal shows the disorganized hyperplastic mucosa region. (E) A section of the polyp (P) region in B, showing extensive proliferation of the glandular structures indicative of adenocarcinoma. The asterisk indicates a region of polyp with lymphocyte infiltration.

Copyright

This image is from Chen Y, Mamm Genome 2006 Mar;17(3):211-9 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:106440

Associated Alleles

Symbol	Name
Smad4^m4Mag	SMAD family member 4; mutation 4, Terry Magnuson