Phenotype Image Detail

Image

Caption

A: Thorax of a 24 week ol Zmpste24^tm1Sgy/Zmpste24^tm1Sgy mouse showing fibrotic lesions surrounding broken ribs (arrows). B: Xray of Zmpste24^tm1Sgy/Zmpste24^tm1Sgy mouse revealing callus formation around rib fractures (arrows). C: CT Scan of the lower thoracic spine of a Zmpste24^tm1Sgy/Zmpste24^tm1Sgy mouse, arrowheads indicate visible callus at the tips of several ribs near the costovertebral joints. D: CT scan of the lower thoracic spine showing multiple rib fractures (arrowheads) in Zmpste24^tm1Sgy/Zmpste24^tm1Sgy mice. E & F: Hematoxylin- and eosin stained sections of rib fractures (arrows) and surrounding fibrosis (arrowheads). G: Avulsion of a fragment of bone (arrowhead) from the cortex of the humerus. H: Fracture of the mandible with fibrosis between bone fragments (arrowhead).

Copyright

This image is from Bergo MO, Proc Natl Acad Sci U S A 2002 Oct 1;99(20):13049-54. Copyright 2002 National Academy of Sciences, U.S.A. J:79501

Associated Alleles

Symbol	Name
Zmpste24^tm1Sgy	zinc metallopeptidase, STE24; targeted mutation 1, Steven G Young

Associated Genotypes

Allelic Composition	Genetic Background
Zmpste24^tm1Sgy/Zmpste24^tm1Sgy	involves: 129S4/SvJae * C57BL/6