Phenotype Image Detail

Image

Caption

A-C: Top, lateral and bottom surfaces of the skulls of 8 week old Zmpste24^tm1Sgy/Zmpste24^tm1Sgy and Zmpste24^tm1Sgy/Zmpste24⁺ mice. Arrowheads show the destroyed zygomatic arch in in A and C; an arrow indicates the small mandible in B. D: Maximal intensity projection of the lateral view of the skulls of 8 week old mice showing an increase in the length of the incisors and size of other teeth. E: Surface rendering of thoracic spines of 8 week old Zmpste24^tm1Sgy/Zmpste24^tm1Sgy amd Zmpste24^tm1Sgy/Zmpste24⁺ mice showing increased pock marks in the Zmpste24^tm1Sgy/Zmpste24^tm1Sgy mice. F: Surface rendering of the femur, knee, tibia/fibula of 8 week old Zmpste24^tm1Sgy/Zmpste24^tm1Sgy and Zmpste24^tm1Sgy/Zmpste24⁺ mice, revealing increased pock marks in the proximal fibula of the Zmpste24^tm1Sgy/Zmpste24^tm1Sgy mouse as well as effacement of the tibial turerosity.

Copyright

This image is from Bergo MO, Proc Natl Acad Sci U S A 2002 Oct 1;99(20):13049-54. Copyright 2002 National Academy of Sciences, U.S.A. J:79501

Associated Alleles

Symbol	Name
Zmpste24^tm1Sgy	zinc metallopeptidase, STE24; targeted mutation 1, Steven G Young

Associated Genotypes

Allelic Composition	Genetic Background
Zmpste24^tm1Sgy/Zmpste24^tm1Sgy	involves: 129S4/SvJae * C57BL/6