Phenotype Image Detail

Image

Caption

A & B: Oil-Red-O staining of frozen liver sections of 4-5 week old Acadl^tm1Uab/Acadl⁺ (left) and Acadl^tm1Uab/Acadl^tm1Uab (right) mice after 18 to 20 hour fast indicate large lipid droplets present in the Acadl^tm1Uab/Acadl^tm1Uab mouse. C & D: Comparison of frozen hearts from 14-16 week old Acadl^tm1Uab/Acadl⁺ (left) and Acadl^tm1Uab/Acadl^tm1Uab (right) mice after 18 to 20 hour fast shows an accumulation in all cardiomyocytes in the Acadl^tm1Uab/Acadl^tm1Uab mouse. E & F: Hemotoxylin-eosin stained heart sections of 16 week old Acadl^tm1Uab/Acadl⁺ (left) and Acadl^tm1Uab/Acadl^tm1Uab (right) nonfasted mice reveals there is prominent myocardial degeneration and fibrosis (arrows) in the Acadl^tm1Uab/Acadl^tm1Uab mouse. Magnification: A & B: X25; C & D: X40; E & F: X10

Copyright

This image is from Kurtz DM, Proc Natl Acad Sci U S A 1998 Dec 22;95(26):15592-7. Copyright 1998 National Academy of Sciences, U.S.A. J:51660

Associated Alleles

Symbol	Name
Acadl^tm1Uab	acyl-Coenzyme A dehydrogenase, long-chain; targeted mutation 1, University of Alabama

Associated Genotypes

Allelic Composition	Genetic Background
Acadl^tm1Uab/Acadl^tm1Uab	involves: 129S6/SvEvTac * C57BL/6NTac