Phenotype Image Detail

Image

Caption

Hematoxylin-eosin and safran colorations of vestibule and cochlea in wild-type (A & C) and Otog^twt/Otog^twt (B & D) mice at 4 days of age, indicates the sensory epithelium of the utricle, the saccule and the crista ampullaris in the wild-type mouse is normally covered by an otoconial membrane (arrow). However, in the Otog^twt/Otog^twt mouse, in the saccule, the otoconial membrane is slightly displaced (arrow); in the utricle, the otoconial membrane is present but fully detached and not visible; but it is clearly present, as seen in the insert; the two cristae ampullares are normally covered by a cupula (arrow). Despite a slight difference in the plane of the sections, both the tectorial membrane (arrowhead) and the sensory epithelium in the cochlea of inner ear of a 4 day old Otog^twt/Otog^twt mouse (D) has a development similar to the inner ear of a 4 day old wild-type mouse (C). Abbreviations: crista ampullaris (CA); saccule (S); utricle (U)

Copyright

This image is from Simmler MC, Mamm Genome 2000 Nov;11(11):960-6 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:65390

Associated Alleles

Symbol	Name
Otog^twt	otogelin; twister

Associated Genotypes

Allelic Composition	Genetic Background
Otog^twt/Otog^twt	involves: C3HeB/Fe * C57BL/6