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Caption | B & C: Skeletal staining, side view comparison, of the head of a Lhx8tm1Lmgd/Lhx8tm1Lmgd (C) with a wild-type control (B) shows that the craniofacial features of the homozygous mutant mouse with cleft palate appears grossly normal. Arrows and arrowheads point at the tip and the middle part of the mandibles in both mice. D & E: Top view of the mandible of the Lhx8tm1Lmgd/Lhx8tm1Lmgd (E) with cleft palate compared to the wild-type control (D). The mandible of the homozygous mutant appears normal. F & G: Ventral view comparison of the upper jaw of the Lhx8tm1Lmgd/Lhx8tm1Lmgd (G) mouse and wild-type control (F) indicates a cleft of the secondary palate (arrowheads) in the homomzygous mutant mouse. H & I: Ventral view comparison of the base of skulls of newborn Lhx8tm1Lmgd/Lhx8tm1Lmgd (I) and wild-type mice (H) stained with alcian blue and alizarin red. The palatal bones in the homozygous mutant failed to grow toward the midline (arrowheads). Scalebar: A: 6.6mm; B-I: 1.3mm | ||||||
Copyright | This image is from Zhao Y, Proc Natl Acad Sci U S A 1999 Dec 21;96(26):15002-6. Copyright 1999 National Academy of Sciences, U.S.A. J:59082 | ||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/27/2024 MGI 6.24 |
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