Phenotype Image Detail

Image

Caption

Photographs are aligned with the pigment epithelium at the top and the vitreal surface at the bottom. At this stage the retina consists of a broad zone of mitotic cells and developing neuroblasts in the outer two-thirds of the retina and a ganglion cells layer in the inner one-third. In the +/+ wild-type retinas, Pou4f1 (A) and Pou4f2 (C) immunoreactivity are found only in ganglion cells. In the homozygous retinas, Pou4f1 immunoreactivity is absent (B), and Pou4f2 immunoreactivity is unaffected (D). In the homozygous mice, no differences in retinal structure are discernible by cresyl violet staining ( E & F). Scalebar: 25um

Copyright

This image is from Xiang M, Proc Natl Acad Sci U S A 1996 Oct 15;93(21):11950-5. Copyright 1996 National Academy of Sciences, U.S.A. J:35877

Associated Alleles

Symbol	Name
Pou4f1^tm1Nat	POU domain, class 4, transcription factor 1; targeted mutation 1, Jeremy Nathans

Associated Genotypes

Allelic Composition	Genetic Background
Pou4f1^tm1Nat/Pou4f1^tm1Nat	involves: 129S7/SvEvBrd * C57BL/6J