Phenotype Image Detail

Image

Caption

The coronal section shows the medial habenula at the point of its greatest lateral extent. The dorsal third ventricle is seen at the center of each section. In +/+ wild-type mice, Pou4f1 immunoreactive neurons are present at high density in the medial habenula and at lower density in the lateral habenula (A). In Pou4f1^tm1Nat/Pou4f1^tm1Nat mice, Pou4f1 immunoreactivity is absent (B). Cresyl violet staining shows a loss of neurons in the medial labenula in homozygous mice ( C & D). Abbreviations: medial habenula (MH); lateral habenula (LH); hippocampus (Hi) Scalebar: 100um

Copyright

This image is from Xiang M, Proc Natl Acad Sci U S A 1996 Oct 15;93(21):11950-5. Copyright 1996 National Academy of Sciences, U.S.A. J:35877

Associated Alleles

Symbol	Name
Pou4f1^tm1Nat	POU domain, class 4, transcription factor 1; targeted mutation 1, Jeremy Nathans

Associated Genotypes

Allelic Composition	Genetic Background
Pou4f1^tm1Nat/Pou4f1^tm1Nat	involves: 129S7/SvEvBrd * C57BL/6J