Phenotype Image Detail

Image

Caption

In +/+ wild-type mice at e20, Pou4f1 immunoreactive neurons are present in the superior colliculus, dorsal central grey, red nucleus and the interpeduncular nucleus (A); Pou4f2 immunoreactive neurons are present in the superior colliculus, dorsal central grey and the interpeduncular nucleus (C). In Pou4f1^tm1Nat/Pou4f1^tm1Nat mice, Pou4f1 immunoreactivity is absent (B), and Pou4f2 immunoreactivity is unchanged (D). By cresyl violet staining, the large neurons of the red nucleus are absent (E & F) (arrows in F indicate expected location of the red nucleus). Abbreviations: aquaduct (Aq); dorsal central grey (DCG); interpeduncular nucleus (IP); red nucleus (RN) superior colliculus (SC). Scalebars: A-D: 200um; E & F: 400um

Copyright

This image is from Xiang M, Proc Natl Acad Sci U S A 1996 Oct 15;93(21):11950-5. Copyright 1996 National Academy of Sciences, U.S.A. J:35877

Associated Alleles

Symbol	Name
Pou4f1^tm1Nat	POU domain, class 4, transcription factor 1; targeted mutation 1, Jeremy Nathans

Associated Genotypes

Allelic Composition	Genetic Background
Pou4f1^tm1Nat/Pou4f1^tm1Nat	involves: 129S7/SvEvBrd * C57BL/6J