Phenotype Image Detail

Image

Caption

For each staining condition, pairs of sections are shown from the rostral and caudal regions of the inferior olivary nucleus. In +/+ wild-type mice, the patterns of Pou4f1 (A & C) and Pou4f2 (E & G) immunoreactivity are similar in both rostral and caudal regions of the inferior olivary nucleus, except tha Pou4f2 immunoreactivity is weak or absent in the dorsal division in the caudal region (vertical arrows in C & G). In Pou4f1^tm1Nat/Pou4f1^tm1Nat mice, Pou4f1 immunoreactivity is absent (B & D), and Pou4f2 immunoreactivity shows little change (F & H). Cresyl violet staining shows a diminution in the number of cells in the caudal region of the inferior olivary nucleus (I-L_. Scalebar; 100um

Copyright

This image is from Xiang M, Proc Natl Acad Sci U S A 1996 Oct 15;93(21):11950-5. Copyright 1996 National Academy of Sciences, U.S.A. J:35877

Associated Alleles

Symbol	Name
Pou4f1^tm1Nat	POU domain, class 4, transcription factor 1; targeted mutation 1, Jeremy Nathans

Associated Genotypes

Allelic Composition	Genetic Background
Pou4f1^tm1Nat/Pou4f1^tm1Nat	involves: 129S7/SvEvBrd * C57BL/6J