Phenotype Image Detail

Image

Caption

Radial sections in lower magnification (upper) and photoreceptors at higher magnification (lower). For both +/+ wild-type and Plcb4^tm1Dwu/Plcb4^tm1Dwu mice there was little variation across retinal eccentricities; average thickness for wild-type was 188 +/-8 and for the homozygous mutants 208 +/-3. In addition, retinal morphology in the homozygous mutant (right) appeared normal compared with that in the wild-type mouse. Abbreviations: pigment epithelium (PE); outer segment (OS); inner segment (IS); outer nuclear alyer (ONL); outer plexiform layer (OPL); inner nuclear layer (INL); inner plexiform layer (IPL) ganglion cell layer (GCL).

Copyright

This image is from Jiang H, Proc Natl Acad Sci U S A 1996 Dec 10;93(25):14598-601. Copyright 1996 National Academy of Sciences, U.S.A. J:77638

Associated Alleles

Symbol	Name
Plcb4^tm1Dwu	phospholipase C, beta 4; targeted mutation 1, Dianqing Wu

Associated Genotypes

Allelic Composition	Genetic Background
Plcb4^tm1Dwu/Plcb4^tm1Dwu	involves: 129S1/Sv