Phenotype Image Detail

Image

Caption

Ultrastructure of photoreceptors of 11 day old Aipl1^tm1Visu/Aipl1^tm1Visu and wild-type littermate. (a and b) Electron micrographs of wild-type and Aipl1^tm1Visu/Aipl1^tm1Visu mouse retina (magnification, x900). Both outer and inner segments are considerably shorter in the homozygous mouse retina. The nuclei in the outer nuclear layer of the homozygous mice are not arranged as a regular array, but are missing some nuclei and show early signs of cell death. (c-e) Although the majority of photoreceptors in the homozygous mice are short and highly disorganized (arrows in d & e), some photoreceptors with normal packing of disks and shorter outer segments are also found. In comparison, in wild-type retina most of the photoreceptors are organized and longer (arrows in c). Several vacuolar inclusions were observed only in the inner segments of the homozygous mutant mice. (indicated by asterisks in d & e).

Copyright

This image is from Ramamurthy V, Proc Natl Acad Sci U S A 2004 Sep 21;101(38):13897-902. Copyright 2004 National Academy of Sciences, U.S.A. J:92617

Associated Alleles

Symbol	Name
Aipl1^tm1Visu	aryl hydrocarbon receptor-interacting protein-like 1; targeted mutation 1, Visvanathan Ramamurthy

Associated Genotypes

Allelic Composition	Genetic Background
Aipl1^tm1Visu/Aipl1^tm1Visu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J