Phenotype Image Detail

Image

Caption

Krt71^Mhdarco13/⁺ or Krt71^Mhdarco13/Krt71^Mhdarco13 and wild-type hair follicles and hair shafts on postnatal day 10. A-C: Semithin sections stained with toluidine blue; Cross sections through dorsal pelage hair follicles at the level of full keratinization of Henle's layer of the IRS. The outlines of Henle's (arrows) and Huxley's layers of the IRS are irregular in the homozygous or heterozygous mutant mouse hair follicles (b,c) in comparison with the wild-type (a). At higher magnification, round areas that are less well stained are seen in the homozygous mutant's Henle's layer (arrows in c). The morphology of the hair cortex and medulla does not appear to be affected. D: SEM images of plucked dorsal pelage hairs of wild-type (left) and Krt71^Mhdarco13/⁺ or Krt71^Mhdarco13/Krt71^Mhdarco13 (right). The homozygous or heterozygous mutant mouse hair shaft is slightly curved compared with the wild-type mouse, but the hair cuticle is continous and normally formed. Abbreviations: scanning electron microscopic (SEM); Huxley's layers (Hu); cortex (Co); medulla (Me). Scalebar: 10um

Copyright

This image is from Runkel F, Mamm Genome 2006 Dec;17(12):1172-82 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:116206

Associated Alleles

Symbol	Name
Krt71^Mhdarco13	keratin 71; Martin Hrabe de Angelis reduced coat 13

Associated Genotypes

Allelic Composition	Genetic Background
Krt71^Mhdarco13/Krt71^Mhdarco13	C3HeB/FeJ-Krt71^Mhdarco13
Krt71^Mhdarco13/Krt71^+	C3HeB/FeJ-Krt71^Mhdarco13