Phenotype Image Detail

Image

Caption

Temporal posterior retinas from Tub^tub/Tub^tub mice at 3 (A) and 11 (B) weeks of age, depicting the region of photoreceptor inner and outer segments. The irregular membranous profiles of outer segments are apparent. At 3 weeks of age, the subretinal space is filled with vesicular membrane-bound profiles (arrow) that are of the same electron density as that of adjacent degenerating inner segments (*). The quantity of these vesicular profiles is most abundant between 3 and 5 weeks; at later times, they are observed less frequently. C: Photoreceptor-cell cilia appear normal at all stages, exhibiting the typical 9+0 arrangement of microtubule pairs. Abbreviations: outer segments (OS); outer limiting membrane (OLM).

Copyright

This image is from Heckenlively JR, Proc Natl Acad Sci U S A 1995 Nov 21;92(24):11100-4. Copyright 1995 National Academy of Sciences, U.S.A. J:121993

Associated Alleles

Symbol	Name
Tub^tub	TUB bipartite transcription factor; tubby

Associated Genotypes

Allelic Composition	Genetic Background
Tub^tub/Tub^tub	B6(AU)-Tub^tub/J