Phenotype Image Detail

Image

Caption

A: Liver section with Oil-Red O stain of wild-type mouse following a 24 hour fast shows no evidence of hepatic steatosis. B: Hepatosteatosis in Acadm^tm1Uab/Acadm^tm1Uab mouse following a 24 hour fast. Oil-Red O stained liver sections reveal severe and diffuse microvesicluar and macrovesicular hepatic steatosis. C & D: Diffuse cardiomyopathy with chronic active multifocal myocyte degeneration and necrosis in homozygous mutant mice.

Copyright

This image is from Tolwani RJ, PLoS Genet 2005 Aug;1(2):e23, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:115759

Associated Alleles

Symbol	Name
Acadm^tm1Uab	acyl-Coenzyme A dehydrogenase, medium chain; targeted mutation 1, University of Alabama

Associated Genotypes

Allelic Composition	Genetic Background
Acadm^tm1Uab/Acadm^tm1Uab	involves: 129P2/OlaHsd * C57BL/6