Phenotype Image Detail

Image

Caption

Gross and histological appearance of gut polyps and lymphoid hyperplasia in wild-type and Pten^tm1Rps/Pten⁺ mice. A: A 5-mm polyp at the colorectal boundary. B: Two polyps in the jejunum of diameters of 2.5 and <1 mm. C-E: Paraffin embedded wild-type and Pten^tm1Rps/Pten⁺ mouse intestine sections stained with hematoxylin and eosin. Arrow indicates luminal side of the lymphoid aggregate. (c) Lymphoid aggregate in the colon of the wild-type mouse. (d) Lymphoid aggregate in the small intestine of the wild-type mouse. (e) Lymphoid aggregate in the small intestine of the heterozygous mouse. Note association of polyp growth with the Peyer's patch. F: A pedunculated polyp of the colon with hyperplasia and a lymphoid aggregate in the center. G: Hyperplastic polyp of the jejunum. H: Retention polyp of the colon. I: Heterozygous female with lymphadenopathy of neck and axilla (arrows). J & K: Paraffin sections of (j) paracortical and medullary effacement and (k) paracortical effacement and follicular hyperplasia of the heterozygous mice, Magnification: A: x6; B: x20; C, E & G: x100; D, F, H, J & K: x40

Copyright

This image is from Podsypanina K, Proc Natl Acad Sci U S A 1999 Feb 16;96(4):1563-8. Copyright 1999 National Academy of Sciences, U.S.A. J:53065

Associated Alleles

Symbol	Name
Pten^tm1Rps	phosphatase and tensin homolog; targeted mutation 1, Ramon Parsons

Associated Genotypes

Allelic Composition	Genetic Background
Pten^tm1Rps/Pten^+	involves: 129S1/Sv * C57BL/6J