Phenotype Image Detail

Image

Caption

Elevated serum TSH levels in Thrb^tm1.1Syc/Thrb^tm1.1Syc mice (A) and increases in the number of thyrotrophs (B). A: Mean TSH levels in Thrb^tm1.1Syc/Thrb⁺ and Thrb^tm1.1Syc/Thrb^tm1.1Syc mice were 2.1 and 411-fold elevated in 3 to 4 month old mice, respectively. The horizontal bars represent mean values. B: TSH-secreting cells were increased in the pituitary of the homozygous mutant mice. TSH-positive cells, indicated by arrows, were counted. The number of cells counted in the pituitary of the wild-type (a) and homozygous mutant mice were 866 and 655, respectively.

Copyright

This image is from Kaneshige M, Proc Natl Acad Sci U S A 2000 Nov 21;97(24):13209-14. Copyright 2000 National Academy of Sciences, U.S.A. J:65885

Associated Alleles

Symbol	Name
Thrb^tm1.1Syc	thyroid hormone receptor beta; targeted mutation 1.1, Sheue-yann Cheng

Associated Genotypes

Allelic Composition	Genetic Background
Thrb^tm1.1Syc/Thrb^tm1.1Syc	involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss