Phenotype Image Detail

Image

Caption

A: Wild-type and Zfp423^nur12/Zfp423^nur12 littermates at P14 photographed midstride shows severe ataxia and reduced weight gain by the mutant mouse. Surface view of littermate brains shows selective loss of the cerebellar vermis. Fluorescence micrographs with Calbindin (red), GFAP (green), and DAPI (blue) illustrate diminished foliation and heterotopic clusters of Purkinje cells (arrow). Higher-magnification image shows a dendritic aborization in both aligned (Left) and heterotopic (Right) cells in the mutant mouse. B: Sections through E15.5 embryos show midline-based hypoplasia of cerebellum and choroid plexus. Note the anterior rotation of the cerebellum and distortion of the area membranacea superior (arms, arrowheads). C: Dysgenesis of hippocampal formation and enlargement of the lateral ventricles of the homozygous mutant mouse compared with the littermate control. Nuclear DAPI stain reveals pattern of cell bodies. Grid lines in A: 1 mm; Scalebar A: 100um; B: 500um

Copyright

This image is from Alcaraz WA, Proc Natl Acad Sci U S A 2006;103(51):19424-19429. Copyright 2006 National Academy of Sciences, U.S.A. J:114758

Associated Alleles

Symbol	Name
Zfp423^nur12	zinc finger protein 423; neurological 12

Associated Genotypes

Allelic Composition	Genetic Background
Zfp423^nur12/Zfp423^nur12	involves: BALB/c * C57BL/6 * C3H