Phenotype Image Detail

Image

Caption

A: Kidney section from a 50 week old Hmox1^tm1Poss/⁺ mouse stained with Prussian blue for detection of loosely bound ferric iron, shown at low magnification. Stainable renal iron was rarely detectable in heterozygous or wild-type mice. B: Kidney section from a 50 week old Hmox1^tm1Poss/Hmox1^tm1Poss mouse stained with Prussian blue. Note the intense blue positive staining in the proximal cortical tubules (arrows). C: Liver section from a 50 week old heterozygous mouse stained with Prussian blue and at low magnification, displaying no hepatic iron deposits. D: Liver section from 50 week old homozygous mouse stained with Prussian blue, demonstrating iron-loaded Kupffer cells (arrows), as well as diffusely staining hepatocytes. Note the faint-staining regenerative nodule indicative of injury (*). E: High-magnification view of liver from 50 week old heterozygous mouse stained with Prussian blue, displaying no detectable iron in hepatocytes. F: High-magnification view of liver section from 50 week old homozygous mouse stained with Prussian blue, indicating iron-positive granules in hepatocytes (arrowheads), and intensely staining Kupffer cells (arrows). All magnification bars: 100um

Copyright

This image is from Poss KD, Proc Natl Acad Sci U S A 1997 Sep 30;94(20):10919-24. Copyright 1997 National Academy of Sciences, U.S.A. J:79254

Associated Alleles

Symbol	Name
Hmox1^tm1Poss	heme oxygenase 1; targeted mutation 1, Kenneth D Poss

Associated Genotypes

Allelic Composition	Genetic Background
Hmox1^tm1Poss/Hmox1^tm1Poss	involves: 129S2/SvPas * C57BL/6