Phenotype Image Detail

Image

Caption

A: Liver section from 50 week old Hmox1^tm1Poss/⁺ mouse, stained with hematoxylin and eosin and shown at low magnification. B: Liver section from 50 week old Hmox1^tm1Poss/Hmox1^tm1Poss mouse, with typical pattern of lesions. Vascular lesions are indicated by arrows. C: High-magnification view of typical periportal fibrosis and inflammation from a 50 week old homozygous mutant mouse, stained with Masson's trichrome reagent, which reacts with collagen, an indicator of fibrosis, as bright blue. D: High-magnification view of hepatic vascular lesion showin in (b) stained with hematozylin and eosin. Note the proliferation of smooth muscle, the infiltration of neutrophils and lymphocytes into the vessel wall, and the monocytes adhered to the inner vessel wall (arrows). E: High-magnification view of hepatic vascular lesion from a 50 week old homozygous mutant mouse. This section was stained for ferric iron (blue). Note the iron-laden monocytes adhering to the vellel wall (arrows), as well as the iron-laden vascular and connective tissue (arrowheads). F: High-magnification view of kidney section of 75 week old heterozygous or wild-type mouse, stained with hematoxylin and eosin, displaying normal glomerular morophology (arrows). G: Kidney section of a 75 week old homozygous mouse displaying severely damaged glomeruli with membranous proliferation, lobularity, crescent formation, and sclerosis (arrows). All magnification: 100um

Copyright

This image is from Poss KD, Proc Natl Acad Sci U S A 1997 Sep 30;94(20):10919-24. Copyright 1997 National Academy of Sciences, U.S.A. J:79254

Associated Alleles

Symbol	Name
Hmox1^tm1Poss	heme oxygenase 1; targeted mutation 1, Kenneth D Poss

Associated Genotypes

Allelic Composition	Genetic Background
Hmox1^tm1Poss/Hmox1^tm1Poss	involves: 129S2/SvPas * C57BL/6