Phenotype Image Detail

Image

Caption

A & B: Dorsal views of the ossified (red) and cartilaginous (blue) axial skeleton from E17.5 wild-type (a) and Zic2^tm1Jaru/Zic2^tm1Jaru(b) mice. Note that the dorsal aspect of the vertebrae (vertebral arches) was irregularly opened and that abnormal fusions between the rostrocaudally adjacent arches had formed (arrowheads). C & D: Cervical vertebra 2 (C2); thoracic vertebra 1 (T1); lumbar vertebra 1 (L1). C & D: Comparison of wild-type (upper) and homozygous mutant mouse (lower) thoracic vertebra 6 (c, T6) and lumbar vertebra (d, L3). E & F: Hand (H) and foot (F) skeletal patterns also were disorganized. The fourth and fifth metacarpal/metatarsal bones were abnormally fused in the homozygous mutant mouse (f) whereas such fusion was not noted in the wild-type mouse (e) (arrowheads). Similarly, abnormal fusion was found in the carpal (*) and tarsal bones (arrow). Abbreviations: Articular process (ap); transverse process (tp); vertebral arch (va); vertebral body (vb).

Copyright

This image is from Nagai T, Proc Natl Acad Sci U S A 2000 Feb 15;97(4):1618-23. Copyright 2000 National Academy of Sciences, U.S.A. J:60644

Associated Alleles

Symbol	Name
Zic2^tm1Jaru	zinc finger protein of the cerebellum 2; targeted mutation 1, Jun Aruga

Associated Genotypes

Allelic Composition	Genetic Background
Zic2^tm1Jaru/Zic2^tm1Jaru	involves: 129S4/SvJae * C57BL/6