Phenotype Image Detail

Image

Caption

A: Appearance of E14.5 Adm^tm1Unc/Adm^tm1Unc (left) and wild-type (right) embryos in their yolk sacs shortly after dissection from the uterus. Note that the yolk sac (arrowhead ys) of the homozygous mouse embryo is distended with fluid, and its blood vessels are thinner than those of its wild-type littermate. B: The thorarcic cavity of the E13.5 homozygous mouse embryos is considerably enlarged (left) compared with the wild-type littermate (right). The black lines indicate the width of the thoracic cavity just above the diaphragm. C: Severe hydrops fetalis is apparent in the E14.5 homozygous mutant mouse embryos (left), readily visible after their yolk sacs are removed. The arrowheads (s) indicate the outer skin layer of the embryos. D: The extreme hydrops of the homozygous mouse embryos, dissected away from their yolk sacs, is completely general, as indicated by the uniformly swollen back and head. The arrowheads (s) again indicate the outer skin layer. E & F: H & E stain of transverse sections through E14.5 wild-type (e) and homozygous mouse (f) embryos. The homozygous mouse embryo has a fluid-filled thoracic cavity, and the tissues external to the rib cage are markedly swollen. Magnification: E & F x1

Copyright

This image is from Caron KM, Proc Natl Acad Sci U S A 2001 Jan 16;98(2):615-9. Copyright 2001 National Academy of Sciences, U.S.A. J:67044

Associated Alleles

Symbol	Name
Adm^tm1Unc	adrenomedullin; targeted mutation 1, University of North Carolina

Associated Genotypes

Allelic Composition	Genetic Background
Adm^tm1Unc/Adm^tm1Unc	involves: 129S6/SvEvTac