Phenotype Image Detail

Image

Caption

Transverse sections through the hearts of wild-type (upper) and Adm^tm1Unc/Adm^tm1Unc (lower) embryos stained with H & E. A: E13.5 wild-type littermate. D: E13.5 homozygous mouse embryo. The heart of the homozygous mutant is smaller then the heart of its wild-type littermate. B: E14.5 wild-type littermate. E: E14.5 homozygous mutant mouse embryo. The heart of the homozygous mouse is still smaller, and the left ventricle is significantly occluded with increased trabeculae compared with its wild-type littermate. C: E14.5 wild-type littermate. F: E14.5 homozygous mouse embryo. Higher-power magnification of the left ventricle at E14.5 shows an increase in the number of trabeculae, a thinner, convoluted compact zone (ca) and a generally delaminated appearance of the homozygous mouse heart compared with the wild-type. Abbreviations: endocardial cushion (c); septum (s); tricuspid valve (t); mitral valve (m); right ventricle (rv); left ventricle (lv); chamber (ch); conpact zone (cz) Magnification: A, B, D & E: x2; C & F" x10

Copyright

This image is from Caron KM, Proc Natl Acad Sci U S A 2001 Jan 16;98(2):615-9. Copyright 2001 National Academy of Sciences, U.S.A. J:67044

Associated Alleles

Symbol	Name
Adm^tm1Unc	adrenomedullin; targeted mutation 1, University of North Carolina

Associated Genotypes

Allelic Composition	Genetic Background
Adm^tm1Unc/Adm^tm1Unc	involves: 129S6/SvEvTac