Phenotype Image Detail

Image

Caption

A: Normal wild-type kidney (left) and kidney from Uox^tm1Bay/Uox^tm1Bay (right) with linear white streaks in lower cortex and medulla representative of urate deposits in renal tubules and collecting ducts. B: Microscopic view of dialated renal tubules containing bluish-pink material (urate crystals) and desquamated tubular epithelia in lumina. (Hematoxylin and eosin stain) C: Acute tubular necrosis with infiltration of neutrophils at day 14. D: Partial polarization of eosin-stained, ethanol-fixed kidney demonstrating anisotropic urate crystals in renal tubules on left and same field under full polarization on right. E: Subgross view of kidney at 5 weeks of age with moderate hydronephrosis (*) and blue foci in outer cortex (arrow). F: Higher power magnification of E demonstrating tubular atrophy and collapse on left with crowding of glomeruli compared wit hnormal renal tubules on right. Magnification: B & F: x40; C: x20; D: x110; E x5

Copyright

This image is from Wu X, Proc Natl Acad Sci U S A 1994 Jan 18;91(2):742-6. Copyright 1994 National Academy of Sciences, U.S.A. J:16490

Associated Alleles

Symbol	Name
Uox^tm1Bay	urate oxidase; targeted mutation 1, Baylor College of Medicine

Associated Genotypes

Allelic Composition	Genetic Background
Uox^tm1Bay/Uox^tm1Bay	involves: 129S7/SvEvBrd * C57BL/6J