Phenotype Image Detail

Image

Caption

A & B: Calcification of elastic lamellae in the aortic media at 6 weeks; staining with hemotoxylin and eosin (a) or alizarian red (b). C: Aneurysmal dilatation with vessel-wall thinning and calcification of elastic lamellae at 3 months; hemotoxylin and eosin. D - F: Intimal hyperplasia with accumulation of excessive collagen and elastin and smooth muscle-cell proliferation and monocyctic infiltration with fragmentation of elastic lamellae in the media at 3 months. Staining was performed with trichrome blue (d). Verhoeff-van Gieson stain (e), or hemotoxylin and eosin (f). The vessel lumen is at top except in c. Magnification x250

Copyright

This image is from Pereira L, Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3819-23. Copyright 1999 National Academy of Sciences, U.S.A. J:54081

Associated Alleles

Symbol	Name
Fbn1^tm2Rmz	fibrillin 1; targeted mutation 2, Francesco Ramirez

Associated Genotypes

Allelic Composition	Genetic Background
Fbn1^tm2Rmz/Fbn1^tm2Rmz	involves: 129S1/Sv * 129X1/SvJ