Phenotype Image Detail

Image

Caption

A: External ear and head morphology of a wild-type (Pact +/+, left) and Prkra^tm1Gcs/Prkra^tm1Gcs (Pact -/-, right) mice. Note the extremely reduced size of the pinna as well as the shortened nose and prominent bossing of the forehead of the homzygous mutant mouse as compared to the wild-type mouse. B: Internal ear structure of a wild-type (left) and homozygous mutant (right) mouse. The most abnormal ear structures in the homozygous mouse as seen above the ear canal, tympanic membrane, ossicles, and middle ear space. There is no impairment in the size of the cochlea in the homozygous mouse. Also show in the stapedial artery. Abbreviations: ear canal (ec); tympanic membrane (tm); ossicles (os); middle ear space (mes); cochlea (co); stapedial artery (sa).

Copyright

This image is from Rowe TM, Proc Natl Acad Sci U S A 2006 Apr 11;103(15):5823-8. Copyright 2006 National Academy of Sciences, U.S.A. J:108297

Associated Alleles

Symbol	Name
Prkra^tm1Gcs	protein kinase, interferon inducible double stranded RNA dependent activator; targeted mutation 1, Ganes C Sen

Associated Genotypes

Allelic Composition	Genetic Background
Prkra^tm1Gcs/Prkra^tm1Gcs	either: B6.Cg-Prkra^tm1Gcs or (involves: C57BL/6)