Phenotype Image Detail

Image

Caption

A-D: Pkd1^tm1Rsa/Pkd1^tm1Rsa embryos at E13.5 (b and d) were edematous and hemorrhagic compared with littermate controls (a and c). Magnetic resonance imaging demonstrated the marked edema (*), subcutaneous hemorrhage (white arrow), pericardial effusions (long black arrow), and abnormal craniofacial development (short black arrow) of homozygous mutant embryos (d). Hematoxylin/eosin staining of sagittal sections of E13.5 embryos showed hemorrhagic effusion and disorganization of the myocardial wall and ventricular septum in homozygous embryos (f & h) but not in wild-type littermates ( e & g). I: Transverse section showing heart of a homozygous mutant embryo at E13.5 showing double outlet right ventricle with the large dysplastic cushion mass forming the outlet septum. Abbreviations: left ventricle (lv); right ventricle (rv); double outlet right ventricle (DORV); right atrium (ra); pulmonary trunk (pt); aorta (a); venous valves of the right atrium (vv); outlet septum (*). Magnification: E & F: x10; H: x40; I: x10 Scalebar: A-D: 1mm

Copyright

This image is from Boulter C, Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12174-9. Copyright 2001 National Academy of Sciences, U.S.A. J:72238

Associated Alleles

Symbol	Name
Pkd1^tm1Rsa	polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Richard Sandford

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm1Rsa/Pkd1^tm1Rsa	involves: 129S4/SvJaeSor