Phenotype Image Detail

Image

Caption

Transmission electron micrographs of glomeruli and vascular pole region of wild-type (a) and Nr3c2^tm1Gsc/Nr3c2^tm1Gsc mice at 8 days of age. In the homozygous mice, the macula densa segment of the distal tubule (MD) was enlarged. The extraglomerular mesangium (encircled by a dotted line) showed prominent hyperplasia with granules (arrows in a and b) in almost every cell. Renin immunocytochemistry (c and e) and corresponding phase contrast pictures (d and f) of 8-day-old mice. In homozygous mutant mice (e), staining for renin at the vascular pole region is much more prominent than in wild-type mice (c).

Copyright

This image is from Berger S, Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9424-9. Copyright 1998 National Academy of Sciences, U.S.A. J:77285

Associated Alleles

Symbol	Name
Nr3c2^tm1Gsc	nuclear receptor subfamily 3, group C, member 2; targeted mutation 1, Gunther Schutz

Associated Genotypes

Allelic Composition	Genetic Background
Nr3c2^tm1Gsc/Nr3c2^tm1Gsc	involves: 129P2/OlaHsd * C57BL/6