Phenotype Image Detail

Image

Caption

A: Radiograph comparison of 16 week old bones in Ctsk^tm1Psa/Ctsk^tm1Psa and control mice. Femur,(left). Humeri (center). Note extensive trabeculation of bone-marrow space (beginning at the distal end) in the homozygous mouse. Lumbar vertebrae (right), (note the very dense and irregular distribution of spongiosa in the homozygous mouse). B & C: SEM images of 3-month-old proximal femura (b, with retained epiphyses) and tibiae (c, with epiphyses removed). Note the retention of cancellous bone in the shafts of the homozgous mutant mouse bones. Field widths: b = 7.69 mm; c = 5.84 mm D & E: Histological sections of the meta- and epiphysis of control (d) and homozygous mouse (e) femura embedded in methyl methacrylate and stained with McNeil's tetrachrome. Note the unresorbed primary spongiosa in e. F & G: Histological sections (sagittal plane) through the ventral half of thoracic vertebrae derived from control (f) and homozygous mice (g). Abbreviations: bone marrow (BM); cortical bone (CB); growth plate (GP) Scalebar: D-G: 400um

Copyright

This image is from Saftig P, Proc Natl Acad Sci U S A 1998 Nov 10;95(23):13453-8. Copyright 1998 National Academy of Sciences, U.S.A. J:50934

Associated Alleles

Symbol	Name
Ctsk^tm1Psa	cathepsin K; targeted mutation 1, Paul Saftig

Associated Genotypes

Allelic Composition	Genetic Background
Ctsk^tm1Psa/Ctsk^tm1Psa	involves: 129X1/SvJ * C57BL/6J