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Phenotype Image Detail
Image
Caption A: Macroscopic view of a hepatic hemangioma (arrows) developed in a 17-month-old Tsc1tm1Hin/+ mouse. B: Histology of a hepatic hemangioma shown by HE staining. C: Macroscopic view of a tail of 15-month-old heterozygous mutant mouse showing a knob (arrow). D & E: Histology of a hemangioma developed in the knob in C shown by HE staining. E is an enlarged view of the region enclosed with a rectangle in D. F: Macroscopic view of a uterus leiomyoma/leiomyosarcoma developed in a 16-month-old heterozygous mutant mouse (arrows). G & H: Histology of the leiomyoma/leiomyosarcoma in F shown by HE staining. In G, * and T indicate the endometrium and tumor region, respectively. Arrowheads in H point to mitotic cells. I: Loss of wild-type Tsc1 allele in extra-renal tumor of Tsc1tm1Hin/+ mice Representative results of LOH analysis are shown. Lanes T, tumor; N, normal counterpart. M, size marker; , no input DNA sample. Products from mutant allele (Mut., 220 bp) and from wild-type allele (Wild, 192 bp) are indicated. Scalebars: B,D,E & G: 100um; H: 10um
Copyright This image is from Kobayashi T, Proc Natl Acad Sci U S A 2001 Jul 17;98(15):8762-7. Copyright 2001 National Academy of Sciences, U.S.A. J:70463
Associated
Alleles
Symbol Name
Tsc1tm1Hin TSC complex subunit 1; targeted mutation 1, Okio Hino
Associated
Genotypes
Allelic Composition Genetic Background
Tsc1tm1Hin/Tsc1+ involves: 129S4/SvJae * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory