Phenotype Image Detail

Image

Caption

C: Five Lrp6^Cd/Lrp6^Gt(Ex187)Byg pups with wild-type siblings show mildly (black arrow) to severly (arrows) crooked tails. One pup has an inrregular spine (white arrowhead) whose skeletal staining (D) reveals fused vertebrae (arrow) and a hemi-vertebra (white arrowhead). A Lrp6^Cd/Lrp6^Gt(Ex187)Byg embryo displays exencephaly (e). Abbreviations: dorsal (d); ventral (v)

Copyright

This image is from Carter M, Proc Natl Acad Sci U S A 2005 Sep 6;102(36):12843-8. Copyright 2005 National Academy of Sciences, U.S.A. J:101423

Associated Alleles

Symbol	Name
Lrp6^Cd	low density lipoprotein receptor-related protein 6; crooked
Lrp6^Gt(Ex187)Byg	low density lipoprotein receptor-related protein 6; gene trap Ex187, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Lrp6^Cd/Lrp6^Gt(Ex187)Byg	involves: 129P2/OlaHsd * A