Phenotype Image Detail

Image

Caption

Hematoxylin and eosin stained samples from the wild-type (A) and Acan^cmd/⁺ mice (B & C), toluidine blue-stained sample from a heterozygote (D), and Alcian blue-stained samples from the wild-type (E) and heterozygotes (F) are shown. Spines of heterozygotes show protrusion of discs [Th3~4 (B) and Th4~5 (C)] or marked herniation at C4~5 (D). Note disappearance of apophyseal cartilage and deformation of vertebral bodies in heterozygotes (B-D) while the spines of the wild type show no remarkable changes (A). Note staining around chondrocytes in the cartilage from heterozygotes (F) while diffuse staining patterns are observed in that from the wild type (E). Magnification: A-C: x10; D: X25; E & F: x125

Copyright

This image is from Watanabe H, Proc Natl Acad Sci U S A 1997 Jun 24;94(13):6943-7. Copyright 1997 National Academy of Sciences, U.S.A. J:41498

Associated Alleles

Symbol	Name
Acan^cmd	aggrecan; cartilage matrix deficiency

Associated Genotypes

Allelic Composition	Genetic Background
Acan^cmd/Acan^+	involves: STOCK T t^low Itpr3^tf