Phenotype Image Detail

Image

Caption

Transmission electron micrographs of vertebral discs from 1-year old wild type (A) and age-matched Acan^cmd/⁺ (B), stained by uranyl acetate. The chondrocytes of the heterozygote show degeneration and are packed together. The extracellular matrix shows concentric dense bundle patterns whereas that of the wild type shows fine diffuse patterns. Magnification: X4500

Copyright

This image is from Watanabe H, Proc Natl Acad Sci U S A 1997 Jun 24;94(13):6943-7. Copyright 1997 National Academy of Sciences, U.S.A. J:41498

Associated Alleles

Symbol	Name
Acan^cmd	aggrecan; cartilage matrix deficiency

Associated Genotypes

Allelic Composition	Genetic Background
Acan^cmd/Acan^+	involves: STOCK T t^low Itpr3^tf