Phenotype Image Detail

Image

Caption

Alizarin red S staining of skeleton and base of the skull of 18.5 d old fetal Tg(Col2a1-PTHR1*H223R)AHju/0 (Left), a Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju (Center) and a Pthlh^tm1Hmk/Pthlh^tm1Hmk littermate lacking the transgene (Right). Abbreviations: supraoccipital bone (so); tympanic bulla (ty); sternum (st); vertebrae (vt); metatarsal bones (mt); basoccipital bone (bo); basisphenoid bone (bs).

Copyright

This image is from Schipani E, Proc Natl Acad Sci U S A 1997 Dec 9;94(25):13689-94. Copyright 1997 National Academy of Sciences, U.S.A. J:77639

Associated Alleles

Symbol	Name
Pthlh^tm1Hmk	parathyroid hormone-like peptide; targeted mutation 1, Henry M Kronenberg
Tg(Col2a1-PTHR1*H223R)AHju	transgene insertion A, Harald Juppner

Associated Genotypes

Allelic Composition	Genetic Background
Pthlh^tm1Hmk/Pthlh^tm1Hmk	involves: 129S2/SvPas * C57BL/6
Tg(Col2a1-PTHR1*H223R)AHju/0	involves: C57BL/6
Pthlh^tm1Hmk/Pthlh^tm1Hmk Tg(Col2a1-PTHR1*H223R)AHju/0	involves: 129S2/SvPas * C57BL/6