Phenotype Image Detail

Image

Caption

Histological sections of decalcified tibiae from newborn mouse homozygous for Tg(Col2a1-PTHR1*H223R)AHju (A), mouse homozygous for both Tg(Col2a1-PTHR1*H223R)AHju and Pthlh^tm1Hmk (B), and a mouse homozygous for Pthlh^tm1Hmk (C). The sections were stained with hematoxylin and eosin. THe height of the proliferative chondrocyte layer is indicated by brackets. A-C show pictures at the same magnification. Pthlh^tm1Hmk

Copyright

This image is from Schipani E, Proc Natl Acad Sci U S A 1997 Dec 9;94(25):13689-94. Copyright 1997 National Academy of Sciences, U.S.A. J:77639

Associated Alleles

Symbol	Name
Pthlh^tm1Hmk	parathyroid hormone-like peptide; targeted mutation 1, Henry M Kronenberg
Tg(Col2a1-PTHR1*H223R)AHju	transgene insertion A, Harald Juppner

Associated Genotypes

Allelic Composition	Genetic Background
Pthlh^tm1Hmk/Pthlh^tm1Hmk	involves: 129S2/SvPas * C57BL/6
Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju	involves: C57BL/6
Pthlh^tm1Hmk/Pthlh^tm1Hmk Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju	involves: 129S2/SvPas * C57BL/6