Phenotype Image Detail

Image

Caption

A: Wild-type tubules show continuous peripheral layer of meiocytes with SCP3 staining. B: Nearly 50% of fourth generation Terc^tm1Rdp/Terc^tm1Rdp (G4) tubules exhibit complete absence of or very few meiocytes with SCP3 staining. Green, SCP3 elements; blue, nuclear chromosomes stained with DAPI. C: Rare apoptosis of wild-type seminferous tubules. D: Extensive apoptosis, indicated by green or yellow in the Terc^tm1Rdp/Terc^tm1Rdp seminferous tubules. Red, nuclear staining with propidium iodide.

Copyright

This image is from Liu L, Proc Natl Acad Sci U S A 2004 Apr 27;101(17):6496-501. Copyright 2004 National Academy of Sciences, U.S.A. J:89751

Associated Alleles

Symbol	Name
Terc^tm1Rdp	telomerase RNA component; targeted mutation 1, Ronald DePinho

Associated Genotypes

Allelic Composition	Genetic Background
Terc^tm1Rdp/Terc^tm1Rdp	involves: 129/Sv * C57BL/6J * SJL