Phenotype Image Detail

Image

Caption

A: Images of 5 month old homozygous Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} (TTD/TTD) mouse (left), a compound heterozygous Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^tm2Jmch (TTD/tXPCS) mouse (center) and a wild-type (wt/wt) mouse (right). Inserts: Images of first-round hair loss. B: Histological analysis of the skin of a homozygous (left), compound heterozygous (center) and wild-type mouse (right). Trichothidystrophy(TTD)-associated acanthosis (thicker epidermis, indicated by solid vertical line), pronounced granular layer (indicated by arrows), and sebacious gland hyperplasia (indicated by dotted verticle line) were absent in the epidermis of the compound heterozygote and wild-type mice. Magnification: x400

Copyright

This image is from Andressoo JO, PLoS Biol 2006 Oct;4(10):e322, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:116054

Associated Alleles

Symbol	Name
Ercc2^tm2(ERCC2)Jhjh	excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 2, Jan H J Hoeijmakers
Ercc2^tm2Jmch	excision repair cross-complementing rodent repair deficiency, complementation group 2; targeted mutation 2, James R Mitchell

Associated Genotypes

Allelic Composition	Genetic Background
Ercc2^tm2(ERCC2)Jhjh/Ercc2^tm2(ERCC2)Jhjh	involves: 129P2/OlaHsd * C57BL/6
Ercc2^tm2(ERCC2)Jhjh/Ercc2^tm2Jmch	involves: 129P2/OlaHsd * C57BL/6