Phenotype Image Detail

Image

Caption

Staining of calcified tissue in neonatal mice with alizarin red S. From left to right are wild-type mouse (A), Tg(Col2a1-PTHLH)2Ecw/0 mouse (B) Pthlh^tm1Hmk/Pthlh^tm1Hmk mouse (C) and Pthlh^tm1Hmk/Pthlh^tm1Hmk Tg(Col2a1-PTHLH)2Ecw/0 mouse (D). The Pthlh^tm1Hmk/Pthlh^tm1Hmk mice display inappropriate ossification of the costal cartilage and along the length of the sternum. These abnormalities appear to be largely corrected in the Pthlh^tm1Hmk/Pthlh^tm1Hmk Tg(Col2a1-PTHLH)2Ecw/0 mice (D), in which ossification is confined to the sternebrae and does not extend to the costal cartilage. A magnified view of the cranium (H) shows substantial correction of the accelerated mineralization of the endochondral bones of the cranial base seen in the knockout (G); s, supraoccipital; b, basioccipital; e, exoccipital; t, tympanic ring. The tips of the emerging mandibular incisors can be discerned in both the normal (E) and transgenic (F) animals, but not in the knockout (G) or rescued-knockout (H) mice.

Copyright

This image is from Philbrick WM, Proc Natl Acad Sci U S A 1998 Sep 29;95(20):11846-51. Copyright 1998 National Academy of Sciences, U.S.A. J:50144

Associated Alleles

Symbol	Name
Pthlh^tm1Hmk	parathyroid hormone-like peptide; targeted mutation 1, Henry M Kronenberg
Tg(Col2a1-PTHLH)2Ecw	transgene insertion 2, Eleanor C Weir

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Col2a1-PTHLH)2Ecw/0	involves: C57BL/6 * SJL
Pthlh^tm1Hmk/Pthlh^tm1Hmk	involves: 129S2/SvPas
Pthlh^tm1Hmk/Pthlh^tm1Hmk Tg(Col2a1-PTHLH)2Ecw/0	involves: 129S2/SvPas * C57BL/6 * SJL