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Phenotype Image Detail
Image
Caption Wild-type mice (upper) and Pthlhtm1Hmk/Pthlhtm1Hmk Tg(Col2a1-PTHLH)2Ecw/0 mice (lower) at 2 weeks of age. Normal eruption of incisors and molars (upper) does not occur in the mutant mouse (lower); the radiographic densities apparent in the mandible and maxilla of the mutant mouse represent impacted teeth. Also, the root of the lower incisor extends under the molars to M3 in the normal mandible (arrowhead, upper), whereas the incisor root in the mutant mouse fails to reach M1 (arrowhead, lower), a typical finding in osteopetrosis.
Copyright This image is from Philbrick WM, Proc Natl Acad Sci U S A 1998 Sep 29;95(20):11846-51. Copyright 1998 National Academy of Sciences, U.S.A. J:50144
Associated
Alleles
Symbol Name
Tg(Col2a1-PTHLH)2Ecw transgene insertion 2, Eleanor C Weir
Associated
Genotypes
Allelic Composition Genetic Background
Pthlhtm1Hmk/Pthlhtm1Hmk
Tg(Col2a1-PTHLH)2Ecw/0 		involves: 129S2/SvPas * C57BL/6 * SJL
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory