Phenotype Image Detail

Image

Caption

C: Hematoxylin eosin stained cross-sections through the femoropatellar groove from 9 month old wild-type (upper) and Col9a1^tm1Jae/Col9a1^tm1Jae mice (lower). Note the even thickness and uniform staining of articular cartilage in the normal femoropatellar groove compared to the presence of fibrous tissue in the center (arrow) and signs of chondrocyte proliferation (arrowheads) toward the lateral margin of the femoropatellar groove in the homozygous mutant mouse. D: Hematoxylin eosin stained section through the patella of a wild-type mouse (upper) and homozygous mutant mouse (lower). Compared with the even articular surface of the wild-type patella, the uneven surface of the homozygous mutant mouse patella shows fibrillation (arrow) and areas of increased chondrocyte proliferation (arrowheads). The fibrous tissue to the right represents a portion of the ligamentum patella that folded over during embedding of the specimen. Magnification: C & D: x100

Copyright

This image is from Fassler R, Proc Natl Acad Sci U S A 1994 May 24;91(11):5070-4. Copyright 1994 National Academy of Sciences, U.S.A. J:18628

Associated Alleles

Symbol	Name
Col9a1^tm1Jae	collagen, type IX, alpha 1; targeted mutation 1, Rudolf Jaenisch

Associated Genotypes

Allelic Composition	Genetic Background
Col9a1^tm1Jae/Col9a1^tm1Jae	either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL)